BIOI610

An introduction to approaches for the structural and functional annotation of genome content. Topics covered include the following: ab initio gene/coding sequence discovery; signals and signal sensors (including regulatory sequences); non-protein coding genes and other structural features of genome sequences; similarity searches (orthologs, paralogs, xenologs); clustering of genes by sequence similarity; clusters of orthologous genes; phylogenetic classification of genes; gene ontologies, gene set enrichment analyses; NGS functional assays; integrated genomics circuits; and annotation databases. Prerequisite: BIOI 604